Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient: a case report.
نویسندگان
چکیده
This report documents that coadministration of phenytoin leads to decreased blood concentrations and area under the blood concentration-time curve of sirolimus in a liver transplant patient. It is essential to monitor the blood concentrations of sirolimus and adjust the sirolimus dosage when phenytoin administration begins or ends.
منابع مشابه
Therapeutic Drug Monitoring of Sirolimus,Correlation With Laboratory Parameters In Transplant Patients
Sirolimus is a potent immunosuppressive agent administered as prophylactic agent to prevent rejection after organ transplantation. Sirolimus must be used within a narrow therapeutic window. Due to inter- and intra-variability, sirolimus blood concentrations may be affected, therefore, there is no possibility of predicting the sirolimus blood concentrations based on the dose patients received. T...
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عنوان ژورنال:
- Therapeutic drug monitoring
دوره 25 1 شماره
صفحات -
تاریخ انتشار 2003